Nuclear entry of DNA viruses

Nuclear entry of DNA viruses

DNA viruses undertake their replication within the cell nucleus, and therefore they must first deliver their genome into the nucleus of their host cells. Thus, trafficking across the nuclear envelope is at the basis of DNA virus infections. Nuclear transport of molecules with diameters up to 39 nm is a tightly regulated process that occurs through the nuclear pore complex (NPC). Due to the enor...

Transportin mediates nuclear entry of DNA in vertebrate systems.

Delivery of DNA to the cell nucleus is an essential step in many types of viral infection, transfection, gene transfer by the plant pathogen Agrobacterium tumefaciens and in strategies for gene therapy. Thus, the mechanism by which DNA crosses the nuclear pore complex (NPC) is of great interest. Using nuclei reconstituted in vitro in Xenopus egg extracts, we previously studied DNA passage throu...

Entry and uncoating of enveloped viruses.

Markus LANZREIN,* Andreas SCHLEGELt and Christoph KEMPF1§11 *Institute for Cancer Research, Department of Biochemistry, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway, t University of Colorado at Boulder, Department of Molecular, Cellular and Developmental Biology, Campus Box 347, Boulder, CO 80309-0347, U.S.A., t Institute of Biochemistry, University of Bern, Freiestrasse 3, 3012...

Cell entry by non-enveloped viruses.

Interestingly, cell entry by non enveloped viruses that you really wait for now is coming. It's significant to wait for the representative and beneficial books to read. Every book that is provided in better way and utterance will be expected by many peoples. Even you are a good reader or not, feeling to read this book will always appear when you find it. But, when you feel hard to find it as yo...

Viral Oncogenesis: DNA Viruses